Performing HPC computations in the cloud requires matching capabilities with computational demands. Each project is unique and can benefit from tailoring IaaS to its specific needs. The most recent instances and VMs introduced by CSPs are extremely powerful and can perform advanced computations even for multi-scale and/or multi-domain cases. However, there are cases that require clusters composed by several instances or VMs to decrease wall times or accommodate very large problem. Odycloud can also help you set up these types of clusters. The following are some basic examples of configurations using available resources in the public cloud: